Elizabeth R. Gillies 现为加拿大 The University of Western Ontario 化学系副教授。

报告题目

Self-immolative Linear Polymers: New Backbones, End-caps, and Assemblies

报告时间

2015年10月9日 (星期五) 上午10:00

报告地点

环境资源楼939会议室

报告摘要

Self-immolative polymers are a class of materials that degrade by an end-to-end depolymerization mechanism in response to a stimulus-mediated cleavage of a stabilizing end-cap from the polymer terminus. Relative to conventional stimuli-responsive or biodegradable polymers, they exhibit several unique properties including a degradation time dependent on the degree of polymerization and the ability to change their responsiveness to stimuli by simply changing the end-cap. These aspects make them of increasing interest for a wide variety of applications including sensors, membranes, and controlled drug release. This presentation will describe our group’s progress toward the development of new self-immolative polymer backbones, end-caps and block copolymers. In particular the development of new monomers capable of undergoing cyclization at different rates can enable the rate of depolymerization to be controlled. Polyglyoxylates are also particularly attractive as they can be derived from natural sources and depolymerize to metabolic intermediates. Different end-caps allow the depolymerization to be triggered under a range of different stimuli including changes in pH, reduction potential, and photochemical stimuli. Finally, the development of self-immolative block copolymers enables the controlled assembly of nanomaterials ranging from micelles to vesicles in solution. These systems enable the encapsulation and controlled release of payloads such as anti-cancer drugs.