澳大利亚新南威尔士大学Cyrille Boyer教授学术报告
Engineering Polymeric NanoParticles for Advanced Applications
报告时间 2013 年9 月3 日 (星期二) 下午4:00
报告地点 中科大东区环境资源楼939 会议室
报告时间 2013 年9 月3 日 (星期二) 下午4:00
报告地点 中科大东区环境资源楼939 会议室
报告摘要
Soft core-shell polymeric nanoparticles are an area of great research interest, due to
their potential advantages in the sustained and targeted delivery of therapeutic
payloads. These systems can offer significant improvements in the temporal and spatial
control of drug delivery. In this talk different polymeric nanoparticles that have been
specifically designed to deliver anti-cancer drugs and to image specific tissue, will be
discussed. The first system presented will be based on pH- and redox- responsive
nanoparticles which are able to deliver different payloads in different cellular
compartments. The synthesis and the characterization of these nano-objects will be
outlined in detailed. As an example, the delivery of nitric oxide will be presented using
these nanoparticles for the treatment of liver fibrosis andneuroblastoma. We have also
demonstrated synergistic effect when we combine nitric oxide (NO) with chemotherapy
drugs for the treatment in multi-drugs resistance in cancer. In a second part of this talk,
the synthesis of new hybrid organic/inorganic nanomaterials, based on iron oxide, gold
and gadolinium, will be reported for use as MRI contrast agents. The effect of the
architecture and the nature of polymers will be correlated with the magnetic properties
of these nano-objects. In addition, the polymeric shell of these nanomaterials can be
designed to conjugate with anti-cancer drugs. Finally, I will rapidly mention the use of
hybrid inorganic polymeric nanoparticles for the storage of hydrogen. In this part, I will
present and discuss on the synthesis of magnesium hydride (MgH2) nanoparticles
stabilized and assembled using functional polymer to yield a new generation of
nanomaterials with remarkable hydrogen storage properties.
Soft core-shell polymeric nanoparticles are an area of great research interest, due to
their potential advantages in the sustained and targeted delivery of therapeutic
payloads. These systems can offer significant improvements in the temporal and spatial
control of drug delivery. In this talk different polymeric nanoparticles that have been
specifically designed to deliver anti-cancer drugs and to image specific tissue, will be
discussed. The first system presented will be based on pH- and redox- responsive
nanoparticles which are able to deliver different payloads in different cellular
compartments. The synthesis and the characterization of these nano-objects will be
outlined in detailed. As an example, the delivery of nitric oxide will be presented using
these nanoparticles for the treatment of liver fibrosis andneuroblastoma. We have also
demonstrated synergistic effect when we combine nitric oxide (NO) with chemotherapy
drugs for the treatment in multi-drugs resistance in cancer. In a second part of this talk,
the synthesis of new hybrid organic/inorganic nanomaterials, based on iron oxide, gold
and gadolinium, will be reported for use as MRI contrast agents. The effect of the
architecture and the nature of polymers will be correlated with the magnetic properties
of these nano-objects. In addition, the polymeric shell of these nanomaterials can be
designed to conjugate with anti-cancer drugs. Finally, I will rapidly mention the use of
hybrid inorganic polymeric nanoparticles for the storage of hydrogen. In this part, I will
present and discuss on the synthesis of magnesium hydride (MgH2) nanoparticles
stabilized and assembled using functional polymer to yield a new generation of
nanomaterials with remarkable hydrogen storage properties.
报告人
Cyrille Boyer教授
Cyrille Boyer教授
School of Chemical Engineering, The University of New South Wales, AustraliaCURRENT POSITION
Associate Professor, ARC Future Fellow
RELEVANT EMPLOYMENT HISTORY
Associate Professor, ARC Future Fellow
RELEVANT EMPLOYMENT HISTORY
- 2002-2006 Ph-D student in collaboration with Solvay-Solexis
- 2004-2005 Adjunct lecturer in Inorganic Chemistry at the University of Montpellier II, France.
- 2006 Research Engineer for DuPont Performance Elastomers and Centre National Recherche Française
- 2007-2009 Senior Researcher, The University of New South Wales (UNSW), Australia
- 2009-2012 Australian Post-doctoral Fellow, The University of New South Wales
- 2010-2012 Lecturer at the School of Chemical Engineering, UNSW
- 2012-2013 Senior Lecturer at the School of Chemical Engineering
- 2012-current ARC Future Fellow
- currently Associate Professor at the School of Chemical Engineering
CURRENT RESEARCH INTERESTS
- Synthesis of protein/siRNA-polymer conjugates
- Synthesis of “SMART” hybrid inorganic/organic nano-materials
- Developing new engineering macromolecular tools (click chemistry, thiol-ene)
- Developing new Metal nanoparticles (Iron Oxide Nanoparticles) for simultaneous siRNA/drug delivery and imagery
- New applications of Living/Controlled Free Radical Polymerization
- Synthesis of polymeric nanoparticles for drug delivery and imaging
- Energy: Synthesis of new hybrid organic/inorganic nanoparticles for hydrogen storage
PATENT SUITE
- Ameduri, B.; Boyer, C., Japan Patent, Application Number 2007/051201. (Assignee Toso Companie)
- Ameduri, B.; Boyer, C., M. Hung, United State Patent Application (2009) Application Number: 2008/209302 (Assignee Dupont Performance Elastomers).
- Ameduri, B.; Boyer, C., M. Hung, World Patent Application (2009) Application Number: WO 2008/US80862 (Assignee Dupont Performance Elastomers)
PUBLICATIONS
90 research articles, 2 book chapters and 14 conference papers (see Researcher ID)
16 invited lectures (1 as plenary speaker) since 2009
SELECTED PUBLICATIONS
- K-F. Aguey-Zinsou and C. Boyer (2012) Synthesis and stabilisation of MgH2 nanoparticles via self-assembly, ChemPlusChem, Volume: 77, Issue: 6, pages: 423-426.
- C. Boyer, A.H.Soeriyadi, P.Zetterlund, M.R.Whittaker (2011) Synthesis of Complex Multiblock Copolymers via a Simple Iterative Cu(0)-Mediated Radical Polymerization Approach Macromolecules, 44(20). 8008-8019.
- J.Ferreira, J.Syrett, M.R.Whittaker, D.M.Haddelton, T.P.Davis, C. Boyer (2011) Optimizing The Generation Of Narrow Polydispersity ‘Arm-First’ Star Polymers Made Using RAFT Polymerization Polymer Chemistry, 2, (8), 1671-1677.
- C. Boyer, V.Bulmus, T.P.Davis, V.Ladmiral, J.Liu, S.Perrier (2009) Bioapplications Of RAFT Polymerization. Chemical Reviews 109, 5402-5436.
- C. Boyer, V.Bulmus, J.Liu, T.P.Davis, M.H.Stenzel, C.Barner-Kowollik (2007) Well-Defined Protein-Polymer Conjugates Via In-Situ RAFT Polymerization. Journal of the American Chemical Society 129, 7145-7154.
TEACHING COURSES
CEIC 1001 Organic chemistry, first year (course coordinator)
CEIC8330 Process Engineering in the Petroleum Industry (course coordinator)
FOOD4110/8110 Use of Nanotechnology in Food Industry ENG1000 Introduction to Engineering Design
CEIC6004 & CEIC8105 Advanced Polymers
BABS3061 Polymeric Nanoparticles for Nanomedicine – A New Generation of Drugs
PROFESSIONAL SOCIETIES (MEMBER OF)
Royal Australian Chemical Institue
American Chemical Society
EDITORIAL ROLES
Web Writer for Polymer Chemistry (RSC journal)
Editorial Board of The Scientific World Journal - Materials Science
CONTACT DETAILS
Centre for Advanced Macromolecular Design
School of Chemical Engineering
The University of New South Wales
UNSW SYDNEY NSW 2052
Australia
P: +61 2 9385 4333
F: +61 2 9385 5966
E: cboyer@unsw.edu.au This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Cyrille Boyer.jpg
