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报告题目 |
天然大分子的组装方法研究 南京大学化学化工学院 蒋锡群教授
Gene Delivery Vectors: from Water-Soluble Polycations to Cationic Nanoparticles 武汉大学化学与分子科学学院 黄世文教授 |
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报告时间 |
2011年11月3日(星期四)上午10:00 |
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报告地点 |
科大东区材料楼五楼会议室 |
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报告摘要 |
略 |
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报告人 |
南京大学化学化工学院 蒋锡群教授 武汉大学化学与分子科学学院 黄世文教授 |
蒋锡群
南京大学化学化工学院教授，南京大学高分子科学与工程系主任。1995年以中日联合培养博士生赴日本九洲大学学习并从事高分子材料表面性质的研究。1999年，以博士后身份赴美国威斯康星大学工作一年并从事高分子医用材料的研究。目前主持国家杰出青年基金、国家自然科学基金等项目。拥有二项美国专利和8项国家发明专利并在国际学术刊物上发表了50多篇研究论文。
主研方向： 1． 高分子介观化学与物理。2． 功能高分子。3． 生物医药高分子。
在研项目： 1. 国家杰出青年基金。2. 国家自然科学基金。3. 江苏省“青蓝工程”。4. 江苏省“六大人才高峰”计划。
黄世文
武汉大学化学与分子科学学院教授、博士生导师。生物医用高分子材料教育部重点实验室副主任。1989年毕业于南京大学化学系，获学士学位；1992年于武汉大学化学系获硕士学位，留校从事教学科研工作。2002年于武汉大学化学与分子科学学院获理学博士学位。2000年8月－2002年2月公派赴新加坡Johns Hopkins Singapore Biomedical Center进行合作研究。2005年被聘为武汉大学教授、博士生导师。2008年入选教育部新世纪优秀人才支持计划。目前主要研究方向为生物医用高分子材料，包括药物控释、基因载体、纳米生物材料等。在Advanced Materials, Biomaterials, Small, Bioconjugate Chemistry, Biomacromolecules, Polymer, Macromolecular Bioscience等期刊发表论文40余篇，他人正面引用300次，先后获湖北省自然科学一等奖、二等奖各一次。
近年发表的主要论文：
1.Peng L, Gao Y, Xue YN, Huang SW*, Zhuo RX*. Cytotoxicity and in vivo tissue compatibility of poly(amidoamine) with pendant amino butyl group as a gene delivery vector. Biomaterials, 2010,31, 4467-4476.
2.Xue YN, Liu M, Peng L, Huang SW*, Zhuo RX. Improving gene delivery efficiency of bioreducible poly(amidoamine)s via grafting with dendritic poly(amidoamine)s. Macromolecular Bioscience, 2010, in press. (doi:10.1002/mabi.200900300).
3.Liu M, Chen J, Cheng Y P, Xue YN, Zhuo RX, Huang SW*. Novel Poly(amidoamine)s with Pendant Primary Amines as Highly Efficient Gene Delivery Vectors. Macromolecular Bioscience, 2010, in press. (doi:10.1002/mabi.200900265).
4.Peng L, Liu M, Xue YN, Huang SW*, Zhuo RX*. Transfection and intracellular trafficking characteristics for poly(amidoamine)s with pendant primary amine in the delivery of plasmid DNA to bone marrow stromal cells. Biomaterials, 2009, 30(29), 5825-5833.
5.Liu M, Chen J, Xue YN, Liu WM, Zhuo RX, Huang S W*. Poly(beta-aminoester)s with Pendant Primary Amines for Efficient Gene Delivery. Bioconjugate Chemistry, 2009, 20(12), 2317-2323.
6.Zhang M, Liu M, Xue YN, Huang SW*, Zhuo RX*. Polyaspartamide-Based Oligo-ethylenimine Brushes with High Buffer Capacity and Low Cytotoxicity for Highly Efficient Gene Delivery. Bioconjugate Chemistry, 2009, 20 (3), 440-446.
7.Xue YN, Huang ZZ, Zhang JT, Liu M, Zhang M, Huang SW*, ZHuo RX*. Synthesis and self-assembly of amphiphilic poly(acrylic acid-b-DL-lactide) to form micelles for pH-responsive drug delivery. Polymer, 2009, 50(15), 3706-3713.
8.Huang SW*, Zhuo RX. Recent advances in polyphosphoester and polyphosphoramidate-based biomaterials. Phosphorus Sulfur and Silicon and The Related Elements, 2008, 183 (2-3), 340-348.
9.Zhang JT*, Xue YN, Gao FZ, Huang SW*, Zhuo RX. Preparation of temperature-sensitive poly(N-isopropylacrylamide)/ -cyclodextrin-grafted polyethylenimine hydrogels for drug delivery. Journal of Applied Polymer Science, 2008, 108, 3031-3037.
10.Chen J, Xia XM, Huang SW*, Zhuo RX*. A cleavable-polycation template method for the fabrication of non-crosslinked and porous polyelectrolyte multilayered films. Advanced Materials, 2007, 19, 979.
11.Chen J, Huang SW*, Lin WH, Zhuo RX*. Tunable Film Degradation and Sustained Release of Plasmid DNAfromCleavable Polycation/Plasmid DNA Multilayeres under Reductive Conditions. Small, 2007, 3，636.
12.Chen J, Huang SW*, Liu M, Zhuo RX*, Synthesis and degradation of poly(beta-aminoester) with pendant primary amine. Polymer, 2007, 48(3), 675.
13.Zhang J T, Huang S W, Xue Y N, Zhuo R X. Poly(N-isopropylacrylamide) nanoparticle- incorporated PNIPAAm hydrogels with fast shrinking kinetics. Macromolecular Rapid Communication, 2005, 26, 1346-1350.
14.Zhang J T, Huang S W, Zhuo R X. A novel sol–gel strategy to prepare temperature-sensitive hydrogel for encapsulation of protein. Colloid Polymer Science, 2005, 284,209-213.
15.Zhang J T, Huang S W, Xue Y N, Zhuo R X. Novel Thermal-Sensitive beta-Cyclodextrin-Contained Poly(N-isopropylacrylamide) Hydrogels Cross-linked by Si-O-Si Bonds: Synthesis, Characterization and Prolonging in Vitro Release of 5-Fluorouracil. Chinese Journal of polymer Science, 2005, 23(5), 513-519.
16.Zhang J T, Huang S W, Liu J, Zhuo R X. Temperature Sensitive Poly[N-isopropylacrylamide-co- (acryloyl b-cyclodextrin)] for Improved Drug Release. Macromolecular Bioscience, 2005, 5, 192-196.
17.Zhang JT, Huang SW, Gao FZ, Zhuo RX. Novel temperature-sensitive,β-cyclodextrin-incorporated poly(N-isopropylacrylamide) hydrogels for slow release of drug. Colloid Polymer Science, 2005,283,461-464
18.Zhang XQ, Wang XL, Huang SW, Zhuo RX Liu ZL,In, Mao HQ, Leong KW. Vitro Gene Delivery Using PAMAM Dendrimers with Trimesyl Core. Biomacromolecules, 2005, 6, 341-350.
19.Zhang J T, Huang S W, Wang L L, Zhuo R X. Preparation and Characteristic of Fast-Responsive, Porous Poly(N-isopropylacylamide-co-Acryl Acid) Hydrogels.Chemical Journal of Chinese University，2004，25(12), 2370-2374.
20.Zhang J T, Huang S W , Zhuo RX. Preparation of temperature-sensitive, polyamidoamine dendrimer-incorporated poly(N-isopropylacrylamide) hydrogels with improved responsive properties. Macromolecular Bioscience, 2004, 2004, 4(6), 575-578.
21.Huang S W, Wang J, Zhang P C, Mao H Q, Zhuo R X, Leong K W. Water-soluble and Nonionic Polyphosphoester: Synthesis, Degradation, Biocompatibility and Enhancement of Gene Expression in Mouse Muscle. Biomacromolecules, 2004, 5(2), 306-311.
22.Wu X Y, Huang S W, Zhang J T, Zhuo R X. Preparation and Characterization of Novel Physically Cross-linkedHydrogels Composed of Poly (vinyl alcohol) and Amine-terminated Polyamidoamine Dendrimer. Macromolecular Bioscience, 2004, 4, 71-75.
23.Zhang J T, Huang S W, Zhuo R X. Preparation and Characterization of Novel Temperature Sensitive Poly(N-isopropylacrylamide-co-acryloyl beta-cyclodextrin) Hydrogels with Fast Shrinking Kinetics. Macromolecular Chemistry and Physics, 2004, 205, 107-113.
24.Zhang J T, Huang S W, Cheng S X, Zhuo R X. Synthesis and Characteristics of Poly(N-isopropylacrylamide)/Poly(N-isopropylacrylamide) Interpenetrating Polymer Network as Drug Delivery System. Journal of Polymer Science, Part A, 2004, 42, 1249-1254.
25.Wu X Y, Huang S W, Zhang J T, Zhuo R X. Preparation and Properties of Physically cross-linked Poly (vinyl alcohol)/ Hydroxy-terminated Polyamidoamine Dendrimer Hydrogels. Chemical Journal of Chinese University, 2004, 25(2), 382-384.
26.Wang J, Huang S W, Zhang P C, Mao H Q, Leong KW. Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters. International Journal of Pharmaceutics, 2003, 265(1-2), 75-84.
27.Huang S W, Zhuo R X. Recent progress in polymer-based gene delivery vectors.Chinese Science Bulletin, 2003, 48(13), 1304-1309.
28.Huang S W, Fu L Z, Zhang X Q, Liu H, Li W X, Zhuo R X. Syntheses of polyamidoamine dendrimers starting from a hexadimensional core and application in gene transfer. Science in China Series B, 2003, 46(3), 271-279.
29. Zhang J T, Cheng S X, Huang S W and Zhuo R X. Temperature-sensitive poly(isopropylarylamide) hydrogel with macroporous structure and fast responsive rate. Macromolecular Rapid Communication, 2003, 24(7), 447-451.
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