题目：基于非等活性A2+B3体系的聚胺基酯和聚胺基酰胺的制备及应用
Abstract：
Poly(amino ester)s and poly(amidoamine)s are unique families of synthetic functional polymers that havebeen widely developed for use both as biomedical materialsand polymer therapeutics. The facile synthetic approach to poly(amino esters)s and poly(amido amine)s is via Michael addition polymerization of functional amine monomers with acrylate and acrylamide monomers. In this talk, we illustrate the successful preparation of functional poly(amino ester)s and poly(amido amine)s with various topologies including linear, grafted, hyperbranched and crosslinked structures based on Michael addition polymerization of diacrylates and diacrylamides to trifunctional amineswith unequal reactivity. Some applications, e.g., as gene and drug vectors, smart carries and fluorescence probes, are demonstrated.
摘要：
聚胺基酯和聚胺基酰胺是新型功能高分子材料，正广泛地被开发为生物医用及高分子治疗材料。它们的主要合成途径是通过胺基与丙烯酸酯和丙烯酸胺类单体的迈克尔加成聚合来实现。在此报告中，我们简要概述了非等活性的三功能胺与双丙烯酸酯和双丙烯酸胺类单体的加成聚合成功制备了线形、接枝、支化及网状等不同拓扑结构的聚胺基酯和聚胺基酰胺，并初步探讨了它们作为基因和药物载体、智能响应材料以及荧光探剂等领域中的应用前景。
吴德成个人简历
●研究兴趣/方向 | |||
1. 可控缩聚和可控逐步加聚反应 2. 新型生物相容和生物可降解高分子材料的设计/合成/表征/性能及应用 | |||
3. 新型智能高分子材料的设计/合成/表征/性能及应用 | |||
4. 新型功能高分子及其复合材料的设计/合成/表征/性能及应用 | |||
●过去和当前研究课题 | |||
1. 智能生物可降解水凝胶(2008-现在) 2. 高分子增稠剂(2007-2010, 与宝洁合作) 3. 功能纳米中空硅球材料制备及应用(2007-2009) 4. 聚酰亚胺电镀(2005-现在) 5. 改性碳纳米管在药物及基因输送应用(2004-2006). 6. 生物可降解聚胺基酯在药物及基因输送应用(2002-现在) 7. 活性自由基聚合(ATRP/RAFT) (1998-2001) | |||
●发表文章 | |||
1. Decheng Wu*, Xian Jun Loh, Yunlong Wu, CheeLeng Lay, Ye Liu*. ‘Living’ Controlled in situ Gelling Systems: Thiol-disulfide Exchange Method towards Tailor-made Biodegradable Hydrogels.J. Am. Chem. Soc.132, 15140-15143. (Impact Factor: 8.580; Citation: 0; Citation: 0 (excluding self-citations) 2. Decheng Wu, Lu Shen, Xu Li*, Siew Yee Wong, WuiwuiChauhariTjiu, Ye Liu, Chaobin He*. Multi-walled Carbon Nanotube/Polyimide Composite Thin Films Fabricated by Electrophoretic Deposition. Polymer2010, 51, 2155-2160. (Impact Factor: 3.573; Citation: 0; Citation: 0 (excluding self-citations) 3. Decheng Wu, Ye Liu*, Chaobin He. Thermal- and pH-responsive Degradable Polymers. Macromolecules2008, 41, 18-20. (Impact Factor: 4.539; Citation: 16; Citation: 16 (excluding self-citations) 4. Decheng Wu, Ye Liu*, Xuan Jiang, Chaobin He, Suat Hong Goh, Kam W. Leong. Hyperbranched Poly(amino ester)s with Different Terminal Amine Groups for DNA Delivery. Biomacromolecules2006, 7, 1879-1883. (Impact Factor: 4.502; Citation: 31; Citation: 30 (excluding self-citations) 5. Ye Liu*,Decheng Wu, Weide Zhang, Xuan Jiang,Chaobin He, Tai Shung Chung,Suat Hong Goh, Kam W. Leong. Polyethylenimine (PEI)-Grafted Multiwalled Carbon Nanotubes for Secure Noncovalent Immobilization and Efficient Delivery of DNAAngew. Chem. Int. Ed.2005, 44, 4782-4785. (Impact Factor: 11.829; Citation: 118; Citation: 115 (excluding self-citations) 6. Decheng Wu, Ye Liu*, Chaobin He, Suat Hong Goh. Blue Photoluminescence from Hyperbranched Poly(amino ester)s.Macromolecules2005, 38, 9906-9909. (Impact Factor: 4.539; Citation: 21; Citation: 19 (excluding self-citations) 7. Decheng Wu, Ye Liu*, Ling Chen, Chaobin He, Tai Shung Chung, Suat Hong Goh. 2A2+BB’B” Approach to Hyperbranched Poly(amino ester)s. Macromolecules2005, 38, 5519-5525. (Impact Factor: 4.539; Citation: 33; Citation: 27 (excluding self-citations) 8. Decheng Wu, Ye Liu*, Xuan Jiang, Ling Chen,Chaobin He, Suat Hong Goh, Kam W. Leong. Evaluation of Hyperbranched Poly(amino ester)s of Amine Constitutions Similar to Polyethylenimine for DNA Delivery.Biomacromolecules2005, 6, 3166-3173. (Impact Factor: 4.502; Citation: 21; Citation: 18 (excluding self-citations) 9. Decheng Wu, Ye Liu*, Chaobin He, Tai Shung Chung, Suat Hong Goh, Effect of Chemistries of Trifunctional Amines on Mechanisms of Michael Addition Polymerizations with Diacrylates, Macromolecules2004, 37, 6763-6770. (Impact Factor: 4.539; Citation: 27; Citation: 19 (excluding self-citations) 10. Ye Liu*, Decheng Wu, Yuexia Ma, Guoping Tang, Shu Wang, Chaobin He, Tai Shung Chung, Suat Hong Goh, Novel Poly(amino ester)s Obtained from Michael Addition Polymerizations of Trifunctional Amine Monomers with Diacrylates: Safe and Efficient DNA Carriers, Chem. Comm.2003, 2630-2631. (Impact Factor: 5.504; Citation: 28; Citation: 17 (excluding self-citations) 11. Decheng Wu, Chunyan Hong, Caiyuan Pan*, Weidong He, Study on Controlled Radical Alternating Copolymerization of Styrene with Maleic Anhydride under UV Irradiation, Polym Int.2003, 52, 98-103. (Impact Factor: 2.137; Citation: 10; Citation: 10 (excluding self-citations) 12. Decheng Wu, YingfangZou, Caiyuan Pan*, Controlled Radical Copolymerization of Styrene and Maleic Anhydride under Gamma Radiation in the Presence of Benzyl Dithiobenzoate, Chinese J Polym Sci.2002, 20, 525-530. (Impact Factor: 0.526; Citation: 4; Citation: 1 (excluding self-citations) 13. CheeLeng Lay, Hui Qi Liu, Decheng Wu, Ye Liu*. Poly(ethylene glycol) (PEG)-graft- Hollow Silica Vesicles for Drug Delivery. Chem – Eur. J. 2010, 16,3001-3004. (Impact Factor: 5.382; Citation: 1; Citation: 1 (excluding self-citations) 14. Chunyan Hong*, Yezi You, Decheng Wu, Ye Liu, Caiyuan Pan*. Thermal Control Over the Topology of Cleavable Polymers: from linear to hyperbranched structures. J. Am. Chem. Soc.2007, 129, 5354-5355. (Impact Factor: 8.580; Citation: 23; Citation: 14 (excluding self-citations) 15. Chunyan Hong*, Yezi You*, Decheng Wu, Ye Liu, Caiyuan Pan. Multiwalled Carbon Nanotubes Grafted with Hyperbranched Polymer Shell via SCVP. Macromolecules2005, 38, 2606-2611. (Impact Factor: 4.539; Citation: 64; Citation: 56 (excluding self-citations) 16. Guobin Sun,Decheng Wu,Ye Liu*, Chaobin He, Tai Shung Chung, Suat Hong Goh. pH-Controllable Cyclic Threading/Dethreading of Polypseudorotaxane Obtained from Cyclodextrins and Poly(amino ester). Polymer2005, 46, 3355-3362. (Impact Factor: 3.573; Citation: 8; Citation: 8 (excluding self-citations) 17. Caiyuan Pan*, Lei Tao, Decheng Wu, Synthesis and Characterizations of the Four-armed Amphiphilic Block Copolymer S[poly(2,3-dihydroxypropyl acrylate)-block-poly(methyl acrylate)](4), J. Polym. Sci. Pol. Chem.2001, 39, 3062-3072. (Impact Factor: 3.971; Citation: 13; Citation: 7 (excluding self-citations) | |||
●发表专利 | |||
1. Decheng Wu, Ye Liu, Jianwei Xu, Chaobin He. Copolymers as rheology modifiers. IMR/Z/06271; IMRE ref: 201018.(Filed on Oct15, 2010) 2. Decheng Wu, Ye Liu, CheeLeng Lay. Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel. PCT/SG2009/000445 (Filed on Nov 24, 2009) 3. Ye Liu, Decheng Wu. Polymer functionalized hollow silica and the methods for polymer functionalized silica. US provisional patent application 61/149,777 (Filed on Feb 4, 2009); Hollow silica particle with a polymer thereon. PCT/SG2010/000021 (Filed on Jan 25, 2010) 4. Xu Li, Chaobin He, Decheng Wu, Ye Liu. Fabrication of carbon nanotube/polymer composite thin film through electrophoretic deposition. PCT/SG2007/000354 (Filed onOct 17, 2007) 5. Ye Liu, Decheng Wu, Chaobin He. Stimulus-responsive biodegradable polymers and methods of preparation. US Patent ApplicationNo.11/934,638.(Filed onNov 2, 2007) 6. Ye Liu, Decheng Wu, Chaobin He.Hyperbranched polymers and their applications. PCT/SG2006/000109. (Granted on Dec 31, 2008) |
