杨志谋教授的学术报告

发布人：发布时间：2010-12-18 浏览次数:96

专家学术报告

报告题目	短肽基小分子自组装体系的制备、形貌表征及其应用
报告时间	2010年12月20日(星期一)上午10:00
报告地点	微尺度国家实验室 (十八层大楼) 一楼展厅
报告摘要	请见附件
报告人	杨志谋教授南开大学生命科学院
报告人简介：⑴、现在工作单位及职称⑵、主要研究方向⑶、学术成就简述（100字以内）请见附件!
接待单位联系人：化学与材料学院刘世勇　　电话：3607348
参加者：所有感兴趣的老师和学生

短肽基小分子自组装体系的制备、形貌表征及其应用

自组装在自然界广泛存在。从各类生物大分子（蛋白质与DNA等）到细胞，甚至是生物体（包括人类）都可以看作是由自组装体系组成。如何像大自然一样，从简单的组装单元最终实现具有各类功能的组装体；如何实现多组分的复杂自组装体系；如何理解自组装的驱动力和组装过程？这些问题一直都是科研工作者们愿意花费毕生精力去解答的问题。最终的目标是更好地模拟自然、改造自然。

国际国内的很多课题组都在自组装领域取得了优异的成果。与大多数自组装领域的课题组不同的是，本课题组在短肽类的自组装体系方面开展研究工作。选择短肽的原因是肽类的良好生物相容性和生物活性、易于合成、质量可控等。报告将首先稍微讲一部分课题组负责人在博士阶段的工作，主要是关于使用酶催化这个策略实现肽类分子的自组装，自组装的具体表现形式为水凝胶。报告随后主要讲我们从事独立科研工作后开展的工作，内容涉及自组装小分子水凝胶以及小分子自组装纳米球。在水凝胶方面包括以下方面：

1）小分子水凝胶稳定性提高的策略；2）新型成胶途径探索；3）小分子水凝胶的新用途；4）小分子水凝胶成胶因子新体系。在小分子自组装纳米球方面包括：1）酶促小分子纳米球的制备；2）基于疏水抗癌药物的纳米球；3）纳米球在基因传输等方面的应用。

课题组希望能与感兴趣的同行、专家进行广泛的交流与探讨，开展合作研究，共同作出优异的成绩。

杨志谋

南开大学

生命科学学院

生物活性材料教育部重点实验室　　　 email: yangzm@nankai.edu.cn

求学经历

南京大学高分子系	本科	2001
香港科技大学化学系（师从徐兵教授）	博士	2006
斯坦福大学微生物与病原体系（Professor Matthew Bogyo）	博士后	2007

承担项目：

1.国家自然科学基金项目，酶促超分子水凝胶的合成及应用，项目批准号：20974054，2010-2012。

2.国家自然科学基金项目，细胞培养支架材料- - 多肽自组装小分子水凝胶的制备及其生物相容度评价，项目批准号：31070856，2011-2013。

3. 教育部博士点基金项目新教师类，基于四聚络氨酸的自组装体系：酶促形成及其应用，项目批准号：20090031120025，2010-2012。

Publications, preprints, and Patents

Peer-reviewed Publications

加入南开大学后：

1.　 Ren, C. H.; Song, Z. J.; Zheng, W. T.; Wang, L.; Kong, D. L.; Yang, Z. M.* "Disulfide bond as a cleavable linker for molecular self-assembly and hydrogelation" Chem. Commun., 2011, DOI: 10.1039/C0CC04135A. (影响因子：5.504)

2.　 Wang, H. M.; Wang, Z.; Yi, X. Y.; Long, J. F.; Liu, J. F.; Yang, Z. M.* "Anti-degradation of a recombinant complex protein by incorporation in small molecular hydrogels" Chem. Commun., 2011, DOI: 10.1039/C0CC04249H. (影响因子：5.504)

3.　 Hu, Y. H.; Wang, H. M.;Wang, J. Y.; Kong, D. L.;* and Yang, Z. M.* "Supramolecular Hydrogels Inspired by Collagen for Tissue Engineering" Org. Biomol. Chem., 2010, 8, 3267-3271. (影响因子：3.762)

4.　 Wang, H. M.; Ren, C. H.; Song, Z. J.; Wang, L.; Chen, X. M.; Kong, D. L.; and Yang,Z. M.* "Enzyme-triggered Self-assembly of a Small Molecule: A Supramolecular Hydrogel with Leaf-like Structures and an Ultra-low Minimum Gelation Concentration" Nanotechnology, 2010, 21,225606. (影响因子：3.137).

5.　 Wang, J. Y.; Wang, H. M.; Song, Z. J.; Kong, D. L.; Chen, X. M.; and Yang,Z. M.*"A Hybrid Hydrogel for Efficient Removal of Methyl Violet from Aqueous Solutions" Colloid. Surface. B, 2010, In press. (影响因子：2.600).

6.　 Wang, H. M.; Gao, J.; Wang, J. Y.; Wang, L.;* Kong, D. L.;* and Yang,Z. M.*"Enzyme-assisted formation of nanosphere as a potential carrierfor hydrophobic compounds" Nanotechnology, 2010, 21, 155602. (影响因子：3.137).

7.　 Yang,Z. M.* Wang, L.; Gao, P.; Wang, J. Y.;and Xu, B.* "Introduction of Phenyl Group on Nanofibers Confers Supramolecular Hydrogels with High Elasticity and Rapid Recovery Properties" J. Mater. Chem., 2010, 20, 2128-2132. (影响因子：4.795)

8.　 Wang, J. Y.; Wang, Z. H.; Wang, L.;* Yang, Z. Y.; Kong, D. L.;* and Yang,Z. M.*"Incorporation of Supramolecular Hydrogels into Agarose Hydrogels Affords Novel Materials as Potential Drug Delivery Carriers" J. Mater. Chem., 2009, 19, 7892-7896. (影响因子：4.795)

9.　 Gao, J.; Wang, H. M.; Wang, L.;* Wang, J. Y.; Kong, D. L.;* and Yang,Z. M.*"Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule" J. Am. Chem. Soc., 2009, 131, 11286-11287. (影响因子：8.580)

专利：

1. 　杨志谋、王玲、王怀民、王景玉，中国专利“用于生成稳定小分子水凝胶的多肽衍生物”，

申请号2009102291861.7，申请时间2009年12月15日。

加入南开大学前：

第一作者文章：

10. Yang,Z. M.; Liang, G. L.; Xu, B.^* "Enzymatic Hydrogelation of Small Molecules: A New Way to Generate Biomaterials",Acc. Chem. Res.,2008, 41, 315-326. (影响因子：18.203)

11. Yang,Z. M.; Liang, G. L.; Guo, Z. F.; Guo, Z. H.;Xu, B.^* "Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth", Angew. Chem. Int. Ed., 2007,46, 8216-8219. (影响因子：11.829)

12. Yang,Z. M.; Xu, K. M.; Guo, Z. F.; Guo, Z. H.;Xu, B.^* "Intracellular Enzymatic Formation of Nanofibers Results in Hydrogelation and Cell Death",Adv. Mater.,2007, 17, 3152-3156. (影响因子：8.379)

13. Yang, Z. M., Xu, B.^* "Using Enzyme to Command Molecular Hydrogelation" Adv. Mater. 2006, 18, 3043-3047. (影响因子：8.379)

14. Yang, Z. M.; Gu, H. W.; Fu, D. G.; Gao, P.;Lam, K. J. K.; Xu, B.^{* “}Enzymatic Formation of Supramolecular Hydrogels" Adv. Mater. 2004, 16, 1440-1444. (影响因子：8.379)

15. Yang, Z. M.; Ho, P. L.; Liang, G. L.; Chow, K. H.; Wang, Q. G.; Cao, Y.; Guo, Z. H.; Xu, B.^* "Using beta-Lactamase to Trigger Supramolecular Hydrogelation" J. Am. Chem. Soc. 2007, 129, 266-267. (影响因子：8.580)

16. Yang, Z. M.; Liang, G. L.; Wang, L. Xu, B.^* "Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in vivo" J. Am. Chem. Soc.2006, 128, 3038-3043. (影响因子：8.580)

17. Yang,Z. M.; Liang, G. L.; Ma, M. L.; Gao, Y.; Xu, B.^* "In Vitro and In Vivo Enzymatic Formations of Supramolecular Hydrogels Based on a b-Amino Acid Dipeptidic Derivative", Small, 2007, 3, 558-562. (影响因子：6.171)

18. Yang,Z. M.; Liang, G. L.; Ma, M. L.; Abbah, A. S.; Lu, W. W.; Xu, B.^* "D-glucosamine-based supramolecular hydrogels to improve wound healing" Chem. Commun., 2007, 843-845. (影响因子：5.504)

19. Yang, Z. M.; Liang, G. L.; Xu, B.^* "Supramolecular Hydrogels Based on b-amino acid derivatives" Chem. Commun. 2006,738-740. (影响因子：5.504)

20. Yang, Z. M.; Xu, K. M.; Wang, L.; Gu, H. W.; Wei, H.; Zhang, M. J.; Xu, B.^* "Self-Assembly of Small Molecules Affords Multifunctional Supramolecular Hydrogels for Topically Treating Simulated Uranium Wounds"Chem. Commun. 2005, 4414-4416. (影响因子：5.504)

21. Yang, Z. M.; Xu, B.^*"A Simple Visual Assay Based on Small Molecule Hydrogels for Detecting Inhibitors of Enzymes" Chem. Commun. 2004, 2424-2425. (影响因子：5.504)

22. Yang, Z. M.; Gu, H. W.; Zhang, Y.; Wang, L.; Xu, B.^*"Small Molecule Hydrogels Based on a Class of Antiinflammatory Agents" Chem. Commun. 2004, 208-209. (影响因子：5.504)

23. Yang, Z. M.; Liang, G. L.; Ma, M. L.; Gao, Y.; Xu, B.^* "Conjugates of naphthalene and dipeptides confer molecular hydrogelators with high efficiency of hydrogelation and superhelical nanofibers" J. Mater. Chem., 2007, 17, 850-854.(影响因子：4.795)

24. Yang,Z. M.; Xu, B.^* "Biofunctional Supramolecular Hydrogels Based on the Self-assembly of Small Molecules" J. Mater. Chem. (Inside Cover), 2007, 17, 2385-2393. (影响因子：4.795)

25. Yang,Z. M.; Ma, M. L.; Xu, B.* "Using matrix metalloprotease-9 (MMP-9) to trigger supramolecular hydrogelation",Soft Matter, 2009, 5, 2546-2548. (影响因子：4.869)

26. Yang,Z. M.; Liang, G. L.; Xu, B.^* "Enzymatic Control of the Self-assembly of Small Molecules: A New Way to Generate Supramolecular Hydrogels" SoftMatter, 2007, 2, 515-520.(影响因子：4.869)

27. Yang,Z. M.; Fonović, M.; Verhelst, S. H. L.; Blum, G.; Bogyo, M.^*"Evaluation of a,b-unsaturated Ketone-based Probes for Papain-family Cysteine Proteases", Bioorg. Med. Chem. 2009, 17, 1071-1078.(影响因子：2.822)

28. Yang,Z. M.; Gu, H. W.; Du, J.; Gao, J. H.; Zhang, B.; Zhang, X. X.; Xu, B.^* "Self-assembled Hybrid Nanofibers Confer a Magnetorheological Supramolecular Hydrogel" Tetrahedron 2007, 63, 7349-7357. (影响因子：3.219)

29. Yang, Z. M., Wang, L., Yuan, J., Shen, J., Lin, S. C.^*. "Synthetic Studies on Nonthrombogenic Biomaterials 14: Synthesis and Characterization of Poly(ether-urethane) Bearing Zwitterionic Structure of Phosphorylcholine on Surface"J. Biomater. Sci. Polym. Edn.2003, 707-718.(影响因子：2.505)

30. Lee, J. T.;* Chen, D. Y.;*Yang,Z. M.;* Ramos, A. D.; Bogyo, M. "Design, syntheses, and evaluation of Taspase1 inhibitors", Bioorg. Med. Chem. Lett. 2009, In press (*equal contribution). (影响因子：2.650)

第二作者文章：

31. Deu E.; Yang Z. M.; Wang F.; Klemba M.; Bogyo M.^*"Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts"PLoS One. 2010 5(8).pii: e11985.

32. Wang, Q. G.; Yang,Z. M.; Zhang, X. Q.; Xiao, X. D.; Chang, C. K.^*;Xu, B.^* "A Supramolecular Hydrogel-Encapsulated Hemeas an Artificial Enzyme to Mimics Peroxidase" Angew. Chem. Int. Ed., 2007, 46, 4285-4289.

33. Gu, H. W.; Yang, Z. M.; Gao, J. H.; Chang, C. K.; Xu, B.^*"Heterodimers of Nanoparticles: Formation at a Liquid-Liquid Interface and Particle-Specific Surface Modification by Functional Molecules" J. Am. Chem. Soc.2005, 127, 34-35.

34. Zhang, Y.; Yang, Z. M.; Yuan, F.; Gu, H. W.; Gao, P.; Xu, B.^*"Molecular Recognition Remolds the Self-Assembly of Hydrogelators and Increases the Elasticity of the Hydrogel by 10⁶-Fold" J. Am. Chem. Soc. 2004, 126, 15028-15029.

35. Wang, Q. G.; Yang,Z. M.; Ma, M. L.; Chang, C. K.;* Xu, B.* "High catalytic activities of artificial peroxidase based on supramolecular hydrogel containing heme models",Chem-A Eur. J.,2008, 14, 5073-5078.

36. Wang, Q. G.; Yang,Z. M.; Wang, L.; Ma, M. L.; Xu, B.^* "Molecular Hydrogel-Immobilized Enzymes Exhibit Superactivity and High Stability in Organic Solvents" Chem. Commun. (Hot article), 2007, 1032-1034.

37. Yang, C.; Yang,Z. M.; Gu, H. W.; Chang, C. K.;* Gao, P.; Xu, B.* "Facet-Selective 2D Self-Assembly of TiO2 Nanoleaves via Supramolecular Interactions", Chem Mater,2009, 20, 7514-7520.

38. Wang, W. P.; Yang,Z. M.; Chau, Y.; Xu, B.* "Controlling self-assembly within nanospace for peptide nanoparticle fabrication", Soft Matter,2008, 4, 1617-1620.

39. Wang, Q. G.; Yang,Z. M.; Gao, Y.; Ge, W. W.; Wang, L.; Xu, B.* "Enzymatic hydrogelation to immobilize an enzyme for high activity and stability", Soft Matter,2008, 4, 550-553.

40. Liang, G. L.; Yang,Z. M.; Zhang, R. J.; Li, L. H.; Fan, Y. J.; Kuang, Y.; Gao, Y.; Wang, T.; Lu, W. W.; and Xu, B.* "A supramolecular hydrogel of a D-aminoacid dipeptide for controlled drug release in vivo",Langmuir,2009, 25, 8419-8422.

41. Wang, L., Yang, Z. M., Chen, L., Lin, S. C. "Syntheses and characterization of a novel series of phosphorylcholines containing hydroxyl group" Chem. J. of Chinese Univ.2003, 1034-1036.

42. Gao, Y.; Yang,Z. M.; Kuang, Y.; Ma, M. L.; Li, J. Y.; Zhao, F.; Xu, B.*"Enzyme-instructed Self-assembly of Peptide Derivatives to Form Nanofibers and Hydrogels", Biopolymers: Peptide Sci. 2009, In press.

其它作者文章：

43. Zhang, Y.; Gu, H. W.; Yang, Z. M.; Xu, B.^* "Supramolecular Hydrogels Respond to Ligand-Receptor Interaction" J. Am. Chem. Soc. 2003, 125, 13680-13681.

44. Wang, L.; Yang, Z. M.; Gao, J. H.; Xu, K. M.; Gu, H. W.; Zhang, B.; Zhang, X. X.; Xu, B.^* "A Biocompatible Method of Decorporation: Bisphosphonate Modified Magnetite Nanoparticles to Remove Uranyl Ions from Blood" J. Am. Chem. Soc. 2006, 128,

13358-13359.

45. Liang, G. L.; Xu, K. M.; Li, L. H.; Wang, L.; Kuang, Y.; Yang,Z. M.; Xu, B.* "Using Congo red to report intracellular hydrogelation resulted from self-assembly of small molecules",Chem. Commun., 2007, 4096-4098.

46. Liang, G. L.; Wang, L.; Yang, Z. M.; Koon, H.; Mak, N. K.; Chang, C. K.^*; Xu, B.^* "Using enzymatic reaction to enhance photodynamic therapy effect of porphyrin dityrosine phosphates" Chem. Commun. 2006, 5021-5023.

47. Wang, L.; Zhang, M.; Yang, Z. M.; Xu, B.^* "The first pamidronate containing polymer and copolymer" Chem. Commun. (Highlighted by C&E news) 2006, 2795-2797.

48. Gu, H. W.; Xu, K. M., Yang, Z. M., Chang, C. K.; Xu, B.^* "Synthesis and Cellular Up-take of Porphyrin Decorated Iron Oxide Nanoparticles—A Potential Candidate for Bimodal Anticancer Therapy" Chem. Commun. 2005, 4270-4272.

49. Xu, K. M.; Ge, W. W.;Liang, G. L.; Wang, L.; Yang,Z. M.; Wang, Q. G.; Hsing, I. M.; Xu, B.* 　　"Bisphosphonate-containing supramolecular hydrogels for topical decorporation of uranium-contaminated wounds in mice" Intl. J. Radn. Biol., 2008, 84, 353-362.

50. Chen, L., Wang, L., Yang, Z. M., Shen, J., Lin, S. C. "Synthetic Studies on Blood Compatible Biomaterials 13: A Novel Segmented Polyurethane Containing Phosphorylcholine Structure: Synthesis, Characterization and Blood Compatibility Evaluation" Chinese J. Polym. Sci.2003, 45-50.

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