美国杜克大学（Duke University）, 生物医学工程系

博士， 2005

导师: Dr. Ashutosh Chilkoti

复旦大学, 化学系

学士, 1999

2008年10月－至今，中科院苏州纳米技术与纳米仿生研究所，研究员；

2007年1月－2010年12月, 中国科学院力学所“国家微重力实验室”，客座研究员；

2005年10月－2008年10月, 北京大学工学院生物医学工程系，研究员。

中国化学会青年化学奖，2009年

入选中科院“人才计划”，2008年

北京大学工学院ExxonMobil教学和科研奖，2007年

Duke University (Center for Biomolecular and Tissue Engineering): First annual student achievement award, 2004

Duke University: Lew’s Fellow, 2003 ~2005

ACS (NC Chapter): First Place in the Richard D. Gilbert award in Polymer Science, 2003

复旦大学: 优秀毕业生, 1999年

上海市化学化工学会奖学金, 1998年

复旦大学：建国奖学金, 1997~1998年

复旦大学：香港人赞助优异奖学金暨复旦大学特等奖学金, 1996~1997年

（1）表面引发聚合反应及其在材料表面修饰中的应用，（2）材料的表面修饰及其在生物界面和生物医学工程中的应用，（3）生物传感器（SPR和QCM）和生物芯片（主要是蛋白质微阵列），（4）细胞在图案化表面的行为，主要研究干细胞的诱导分化等。

 “Superhydrophobic Poly(dimethylsiloxane) and methods for making the same” (2008,中国和国际专利申请中)

“A light sensitive initiator integrated Poly(dimethylsiloxane)” (2008,中国和国际专利申请中)

“A light sensitive PDMS for complex pattern formation” (2008,中国和国际专利申请中)

“一种引发剂整合的复合静电纺丝及其制备方法 ” (中国发明专利申请号：200810226258.8)

“一种静电纺丝的表面修饰方法”（中国发明专利申请号：200810239723.1）

“数字多频石英微量天平检测方法“（中国发明专利申请号：200910224159.0）

　　　　 1．“用石英晶体微天平和椭圆偏振仪研究表面引发聚合反应”，《高分子科学前沿与进展II》，董建华主编，科学出版社，北京，2009

　　   　2．“Oligo(ethylene glycol) Based Nonfouling Surfaces—Engineering Flat Surfaces and Microstructures for Biosensors, Tissue Engineering and Biomedical Applications”, VDM Verlag Dr. Müller Aktiengesellschaft & Co. KG, Saarbrücken, Germany (ISBN 978-3-639-15621-8)

37. Directly observed Au-S bond breakage due to swelling of the anchored polyelectrolyte

Yanxia Zhang, Jian’an He, Ying Zhu, Hong Chen, and Hongwei Ma*, Chem. Commun., accepted, 2010

36. Solidified liquid layer model makes quartz crystal microbalance a convenient molecular ruler

Mo Huang, Jian’an He, Jianhong Gan*, and Hongwei Ma*, Colloid and Surface B: Biointerfaces, accepted, 2010

35.  Surface initiated polymerization from substrates of low initiator density and its applications in biosensors

Hongwei Ma*, Jian’an He, Xing Liu, Jianhong Gan, Gang Jin and Jiahai Zhou, ACS Applied Materials and Interfaces, in press, 2010 (DOI: 10.1021/am1006832)

34.  Micropatterning controls smooth muscle myosin heavy chain expression and limits response to transforming growth factor beta 1 in vascular smooth muscle cells

Corin Williams, Xin Q Brown, Erzsebet Bartolak-Suki, Hongwei Ma, Ashutosh Chilkoti and Joyce Y Wong*, Biomaterials, in press, 2010 (doi:10.1016/j.biomaterials.2010.08.105)

33. Integrated Poly(dimethysiloxane) with an Intrinsic Nonfouling Property Approaching

“Absolute” Zero Background in Immunoassays

Hongwei Ma*，Yuanzi Wu, Xiaoli Yang, Xing Liu, Jianan He, Long Fu, Jie Wang, Hongke Xu, Yi Shi and Renqian Zhong, Anal. Chem., 82, 6338–6342, 2010

32. Controlled wrinkle formation via bubble inflation strain engineering

Pengfi Zhang, Dayong Yang, Zhong Li and Hongwei Ma*, Soft Matter, in press, 2010 (DOI: 10.1039/c0sm00298d)

31.  A DNA-origami chip platform for label-free SNP genotyping using toehold-mediated strand displacement

Zhao Zhang, Dongdong Zeng, Hongwei Ma, Guoying Feng, Jun Hu, Lin He,* Can Li,* and Chunhai Fan*, Small, 6，1854-1858，2010

30. Nanofibrous membrane with tunable surface chemistry: preparation and application in protein microarrays

Xing Liu, Dayong Yang*, Gang Jin and Hongwei Ma*, J. Mater. Chem. in press, 2010（DIO：10.1039/c0jm01409e）

29. One-step fabrication of porous polymeric microcage via electrified jetting

Ying Zhu, Dayong Yang* and Hongwei Ma*, Nanoscale,2010, in press

28. 静电纺丝纳米纤维薄膜的应用进展

Mengmeng Li, Ying Zhu, Dayong Yang*, Xinyu Jiang and Hongwei Ma, 高分子通报, 9, 42-51, 2010

27. Poly(dimethylsiloxane) elastomers with tethered peptide ligands for cell adhesion studies

Yuanzi Wu, Sean R. Coyer, Hongwei Ma and Andrés J. García*, Acta Biomaterialia, 6, 2898-2902, 2010

26. A quartz crystal microbalance-based molecular ruler for biopolymers

Hongwei Ma*, Jianan He, Zhiqiang Zhu, Bei’er Lv, Di Li, Chunhai Fan and Jing Fang, Chem. Commun., 46, 949-951, 2010

25. Arranging junctions for nanofibers

Mengmeng Li, Dayong Yang*, Yunze Long and Hongwei Ma*, Nanoscale, 2, 218-221, 2010

24. Electrospinning of poly (dimethylsiloxane) nanofibrous membrane: fabrication and application in protein microarrays

Dayong Yang, Xing Liu, Yu Jin, Ying Zhu, Dongdong Zeng, Xingyu Jiang* and Hongwei Ma*, Biomacromolecules, 10, 3335-3340, 2009

23. Substrate induced controllable wrinkling for facile nanofabrication

Zhong Li, Dayong Yang*, Xing Liu, and Hongwei Ma*, Macromol. Rapid Commun., 30, 1549-1553, 2009

22. Quartz crystal microbalance study of the kinetics of surface initiated polymerization

Xinan Chen, Yaozhong Zhang, Jianan He, Chunyang Xiong, Yonghong Meng, Gang Jin and Hongwei Ma*, Science in China Series B: Chemistry, 50, 2307-2322，2009

21. Real-time measuring the mass of water expelled by poly(N-isopropylacrylamide) brushes upon thermo-induced collapse

Hongwei Ma*, Long Fu, Wei Li, Yaozhong Zhang, and Mingwu Li*, Chem. Comm., 3428-3430, 2009

20. Photoelectric conversion switch based on quantum dots with i-motif DNA scaffolds

Haifeng Meng, Yang Yang, Yingjuan Chen, Yunlong Zhou, Yaling Liu, Xin’an Chen, Hongwei Ma, Zhiyong Tang*, Dongsheng Liu and Lei Jiang, Chem. Comm., 2293-2295, 2009

19. Convergence of dissipation and impedance analysis of quartz crystal microbalance studies

Yaozhong Zhang, Binyang Du*, Xinan Chen, and Hongwei Ma*, Anal. Chem., 81, 642-648, 2009

18. Surface-imprinted nanostructured layer-by-layer film for molecular recognition of theophylline derivatives

Jia Niu, Zhihua Liu, Long Fu, Feng Shi, Hongwei Ma, Yukihiro Ozaki and Xi Zhang*, Langmuir, 24, 11988-11994, 2008

17. Investigation of the interactions between silver nanoparticles and hela cells by scanning 　　　　electrochemical microscopy

Zhong Chen, Shubao Xie, Li Shen, Yu Du, Shali He, Qing Li, Zhongwei Liang, Xin Meng, Bo Li, Xiaodong Xu, Hongwei Ma, Yanyi Huang and Yuanhua Shao*, Analyst, 133, 1221-1228, 2008

16. Superhydrophobic poly(dimethyl siloxane) via surface- initiated polymerization with ultra low initiator density

Tongcheng Qian, Yuefang Li, Yuanzi Wu, Bo Zheng, and Hongwei Ma*, Macromolecules, 41, 6641-6645, 2008

15. Study viscoelasticity of ultra-thin poly(oligo(ethylene glycol) methacrylate) brushes by a quartz crystal microbalance with dissipation

Long Fu, Xinan Chen, Jianan He, Chunyang Xiong and Hongwei Ma*, Langmuir, 24, 6100-6106, 2008

14. A facile method for permanent and functional surface modification of poly(dimethylsiloxane)

Yuanzi Wu, Yanyi Huang, and Hongwei Ma*, J. Am. Chem. Soc., 129, 7226-7227, 2007

13. Study and application of a linear frequency-thickness relation for surface initiated atom transfer radical polymerization in quartz crystal microbalance

Jianan He, Jia Wu, Yuanzi Wu, Xiang Mao, Jing Fang, Chunyang Xiong, Jinlin Xie, and Hongwei Ma*, Macromolecules, 40, 3090-3096, 2007

12. Analysis of long range correlations due to coherent light scattering due from in vitro cell arrays using angle-resolved low coherence interferometry

John W. Pyhtila, Hongwei Ma, Andrew Simnick, Ashutosh Chilkoti, and Adam Wax*, J. Biomedical Optics, 11(3), 2006

11. Monitoring kinetics of surface-initiated atom transfer radical polymerization by quartz crystal microbalance with dissipation

Hongwei Ma, Marcus Textor, Robert L. Clark, and Ashutosh Chilkoti*, Biointerphases, 1, 35-39, 2006

10. Protein resistant polymer coatings on silicon oxide by surface initiated atom transfer radical polymerization

Hongwei Ma, Dejin Li, Bin Zhao, and Ashutosh Chilkoti*, Langmuir, 22, 3751-3756, 2006

09. Surface-initiated atom transfer radical polymerization of oligo(ethylene glycol) methyl methacrylate from mixed self-assembled monolayer on gold

Hongwei Ma, Matthew Wells, Thomas P. Beebe, Jr., and Ashutosh Chilkoti*, Adv. Funct. Mater., 16, 640-648, 2006

08. Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption

Zhanping Zhang, Hongwei Ma, Douglas B. Hausner, Ashutosh Chilkoti, and Thomas P. Beebe, Jr.*, Biomacromolecules, 6, 3388-3396, 2005

07. Fabrication of biofunctionalized quasi 3-dimensional microstructures of a nonfouling comb polymer by soft lithography

Hongwei Ma, Zhanping Zhang, Thomas P. Beebe, Jr., and Ashutosh Chilkoti*, Adv. Funct. Mater., 15, 529-540, 2005

06. “Nonfouling” oligoethylene glycol functionalized “Bottle Brushes” synthesized by surface-initiated atom transfer radical poymerization

Hongwei Ma, Jinho Hyun, Philip Stiller and Ashutosh Chilkoti*, Adv. Mater., 16, 338-341, 2004

05. Surface engineering strategies for control of protein and cell interactions

Nidhi Nath, Jinho Hyun, Hongwei Ma, and Ashutosh Chilkoti*, Surface Science, 570, 98-110, 2004

04. Stimulus-responsive poly(N-isopropylacrylamide) brushes and nanopatterns prepared by Surface-Initiated Polymerization

Marian Kaholek, Woo-Kyung Lee, Sang-Jung Ahn, Hongwei Ma, Kenneth C. Caster, Bruce LaMattina, Stefan Zauscher*, Chem. Mater., 16, 3688-3696, 2004

03. Universal route to cell micropatterning using an amphiphilic comb polymer

Jinho Hyun, Hongwei Ma, Zhanping Zhang, Thomas P. Beebe, Jr., and Ashutosh Chilkoti*, Adv. Mater., 15, 576-579, 2003

02. Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film

Jinho Hyun, Hongwei Ma, Pallab Banerjee, Janet Cole, Kenneth Gonsalves, and Ashutosh Chilkoti*, Langmuir, 18, 2975-2979, 2002

01. Radical-mediated diastereoselective construction of a chiral synthon for synthesis of dolabellanes

Qiang Zhu, Kai-Yi Fan, Hong-Wei Ma, Li-Xin Qiao, Yu-Lin Wu, Yi-kang Wu*, Organic Letters, 1, 757-759, 1999

1. 2007年高分子科学青年学者研讨会（主办单位：国家自然科学基金委员会化学科学部），东华大学，上海，2007年8月5-8日

2. 2008年高分子表界面前沿科学问题研讨会（主办单位：国家自然科学基金委员会化学科学部），南京大学，江苏南京，2008年4月28-30日

3. 第11次中国生物物理学术大会－“纳米生物与成像技术”研讨会（主办单位：中国生物物理学会），广西桂林，2009年7月12-16日

4. 2009年全国高分子学术论文报告会（主办单位：中国化学会高分子学科委员会），南开大学等，天津，2009年8月18-22日

5. 2009年高分子科学青年学者研讨会（主办单位：国家自然科学基金委员会化学科学部），苏州大学，江苏苏州，2009年10月30日-11月1日

6. 2010年第七届全国高聚物分子与结构表征学术讨论会（主办单位：中国化学会高分子学科委员会），华东师范大学，上海，2010年10月11日-14日

从聚电解质刷的溶胀行为预测Au-S键的断裂

马宏伟

中国科学院苏州纳米技术与纳米仿生研究所

关键词：聚电解质渗透压共价键断裂石英晶体微天平

研究表明通过物理作用实现共价键断裂的方法有光、超声、反复冻融等^[1]。这里我们报道一种新的断键的物理方法，即当处于一定盐浓度的磷酸盐缓冲溶液（PBS，pH=7.4，下同）时，接枝到表面的聚电解质刷内部反离子产生的溶胀行为能够导致Au-S键的断裂。我们首先通过表面引发聚合方法（SIP）在石英晶体微天平（QCM）芯片表面接枝甲基丙烯酸寡聚乙二醇酯（OEGMA）和甲基丙烯酸羟乙酯（HEMA）共聚物刷（poly(OEGMA-co-HEMA)），进一步羧基化后得到了聚电解质刷。其次，我们通过QCM对聚电解质刷的溶胀行为以及Au-S键的断裂过程进行了实时监测。图1为不同厚度聚电解质刷在水和PBS（ [Na⁺]=150 mM）中的溶胀情况。可以看出，对于厚度较低的聚电解质刷，PBS的加入导致频率进一步降低，即在PBS中聚电解质刷发生进一步的溶胀。而当其厚度较高时，PBS的引入却使得频率迅速增加，最终达到改性前QCM芯片在PBS中的频率值附近（图中黑色虚线）。 

我们进一步发现这种断键现象不仅与聚电解质刷的厚度有关，同时也与盐离子的浓度（[Na⁺]）有关。从图2可以看出，随着盐离子浓度的增大，频率逐步降低，表明聚电解质刷的溶胀程度逐渐增加。当[Na⁺]=15 mM时，断键现象开始发生。通过分析一系列不同厚度的聚电解质刷在不同盐离子浓度下的溶胀行为，我们发现可以通过聚电解质刷的湿态厚度（T_eff）的大小来预测断键现象的发生。T_eff由聚电解质刷的干态厚度和盐离子浓度共同决定，当T_eff超过一临界值时，Au-S键发生断裂进而导致聚电解质刷脱附。这一发现有望对控制释放、聚电解质的溶液行为等研究产生积极的影响。

参考文献：

[1] Caruso M M, Davis D A, Shen Q, et al., Chem. Rev. 2009, 109:5755.

[2] Zhulina E B, Birshtein T M, Borisov O V, et al.,Macromolecules 1995, 28: 1491.