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Lecommandoux教授报告(2012-9-15)

( 2012-09-12 )
 

报告题目

Biomimetic Block Copolymer Vesicles: towards Smart Nanomedicines

Prof. Sébastien Lecommandoux

Université de Bordeaux, France

报告时间

2012年9月15日 (星期六) 上午10:00

报告地点

微尺度国家实验室 (十八层大楼) 一楼展厅

报告摘要

Polymer vesicles (polymersomes) are one of the most promising systems for drug delivery applications and may offer many advantages compared to low molar mass lipid vesicles. Actually, vesicles obtained by self-assembly of block copolymers are expected to overcome some of the limitations of their lipidic analogues, mainly they low stability and leakiness, and thus allow the development of robust containers of either hydrophilic or hydrophobic species. The development of macromolecular nanodevices that can be used within the living body implies that sensors detecting chemical signals -such as ions, enzymes or pH changes and generating internal signals or appropriate responses be integrated in the macromolecular system. The use of peptide and saccharide building blocks in the copolymer structure would allow both controlling the self-assembled structure and the resultant biofunctionality.

 

We will report an overview on the self-assembly in water of amphiphilic block copolymers into polymersomes, and their applications in loading and controlled release of both hydrophilic and hydrophobic molecules and biomolecules. We will pay special attention to polysaccharide and polypeptide-based block copolymer vesicles that we have studied these recent years in our group. These newly developed copolymers that mimic the structure and function of glycoproteins represent an example of the effectiveness of a biomimetic strategy in implementing materials design. In addition, magnetic polymersomes, including iron oxide γ-Fe2O3 nanoparticles are currently investigated, together with their potential applications as contrast agent for diagnosis and as therapeutic nanoparticles using hyperthermia. Exciting and very promising results about their therapeutic evaluation for tumor targeting and in vivo tumor regression studies will be presented. Finally our recent advances in using “biomimicry approaches” to design complex, compartmentalized materials will be proposed.

报告人单位

Université de Bordeaux, France

合肥微尺度物质科学国家实验室

中科院软物质化学重点实验室

高分子科学与工程系

 
 
Sébastien Lecommandoux
Professor at the Université de Bordeaux
Laboratoire de Chimie des Polymères Organiques
UMR CNRS 5629
IPB-ENSCBP
FRANCE
   Pr. Sébastien Lecommandoux received his PhD degree in Chemistry and Physics in 1996 at the University of Bordeaux, supervised by Prof. F. Hardouin (CRPP). Then, he went to the Materials Research Laboratory and the Beckman Institute (University of Illinois at Urbana-Champaign, USA) and worked as a Post-Doc in the group of Prof. S. I. Stupp. Here, he learned the art of self-assembly and supramolecular chemistry. Subsequently, he joined the Laboratoire de Chimie des Polymères Organiques (Bordeaux, France) as Associate Professor in 1998, and became Full Professor in 2005.
 
  His current research interests mainly focus on macromolecular engineering via block copolymer selfassembly, and the use of these supramolecular systems for drug delivery applications. He has received several scientific awards, including the bronze medal of the CNRS in 2004 and a position at the Institut Universitaire de France (IUF) in 2007.

   He supervised about 15 PhD students and published more than 100 publications in international journal, 5 book chapters and 4 patents. He did more than 100 communications, including about 80 orals and 60 on invitation. He is also in the international Editorial Board of several journals: “Biomacromolecules” (ACS), “Polymer Chemistry” (RSC), “The Open Macromolecules Journal” (Bentham Science Publishers). His Hirsch index is 28; his publications have been cited over 3,000 times.

   He is currently leading the group of “Polymer Nanotechnology for Life Sciences” at the LCPO-University of Bordeaux. He is involved in several ANR research programs in France, and is SP leader in a FP7 Europe Project (Nanother) dedicated to the development of polymer nanoparticles in cancer therapy. He is currently leading the RNP-ESF program on “Precision Polymer Materials” and is involved in two other COST programs on “bio-inspired materials” and “PET-MRI imaging”. His recent topics concern the development of smart biomimetic polymersomes based on polypeptide and polysaccharide, the formation of magnetic hybrid polymer vesicles for therapy and imaging (theranostics).

 
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